FOXO1 CLIA Kit for Human(Homo sapiens) | EIAab.comFOXO1 CLIA Kit for Human(Homo sapiens)

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FOXO1 (Gene name),

Forkhead box protein O1 (Protein name ), FOXO1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

FOXO1(FKHR;FOXO1A);

Protein name:

Forkhead box protein O1;

Alternative:

Forkhead in rhabdomyosarcoma;Forkhead box protein O1A;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with LRPPRC (By similarity). Interacts with SIRT1 and this interaction requires the presence of KRIT1 (By similarity). Interacts with NLK (By similarity). Binds to CDK1 and 14-3-3 proteins.

Function:

Transcription factor which acts as a regulator of cell responses to oxidative stress. In the presence of KIRT1, mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence (By similarity). Triggers death of postmitotic neurons when phosphorylated by CDK1. Activates transcription of PMAIP1.

Subcellular Location:

Cytoplasm Nucleus Shuttles between cytoplasm and nucleus. Translocates to the nucleus upon oxidative stress induced phosphorylation at Ser-212 by STK4/MST1.

Protein Attributes:

Sequence length:

655

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

655:

SWVSG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2308

String:

Q12778

SMR:

Q12778

MIM:

136533

STRING:

9606.ENSP00000368880

Pfam:

PF00250

UniGene:

Hs.370666

Uniprot:

Q12778

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ELISA Kit for Human Forkhead box protein O1

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E0764m

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96T

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ELISA Kit for Human Forkhead box protein O1

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E0764h

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96T

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ELISA Kit for Human Forkhead box protein O1

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E0764r

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96T

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ELISA Kit for Human Forkhead box protein O1

Cat.:

E0764p

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96T

ELISA Kit for Human Forkhead box protein O1

Cat.:

E0764b

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96T

CLIA Kit for Human Forkhead box protein O1

Cat.:

U0764p

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96T

CLIA Kit for Human Forkhead box protein O1

Cat.:

U0764m

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MSDS:

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Packing:

96T

CLIA Kit for Human Forkhead box protein O1

Cat.:

U0764b

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96T

CLIA Kit for Human Forkhead box protein O1

Cat.:

U0764h

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Manual:

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96T

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CLIA Kit for Human Forkhead box protein O1

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U0764r

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96T

Polyclonal Antibody for Human Forkhead box protein O1

Cat.:

P0764Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Forkhead box protein O1

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P0764Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Forkhead box protein O1

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P0764Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Forkhead box protein O1

Protein for Human Forkhead box protein O1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma."
Galili N. , Davis R.J. , Fredericks W.J. , Mukhopadhyay S. , Rauscher F.J. III , Emanuel B.S. , Rovera G. , Barr F.G.
Nat. Genet.5:230-235(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH PAX3
2.

"Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily."
Anderson M.J. , Viars C.S. , Czekay S. , Cavenee W.K. , Arden K.C.
Genomics47:187-199(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Rhabdomyosarcoma.
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
tissue: Placenta.
6.

"Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma."
Davis R.J. , D'Cruz C.M. , Lovell M.A. , Biegel J.A. , Barr F.G.
Cancer Res.54:2869-2872(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PAX7
7.

"Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B."
Rena G. , Guo S. , Cichy S.C. , Unterman T.G. , Cohen P.
J. Biol. Chem.274:17179-17183(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-24; SER-256 AND SER-319
8.

"Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence."
Guo S. , Rena G. , Cichy S. , He X. , Cohen P. , Unterman T.
J. Biol. Chem.274:17184-17192(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;PHOSPHORYLATION AT SER-256;FUNCTION
9.

"The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site."
Woods Y.L. , Rena G. , Morrice N. , Barthel A. , Becker W. , Guo S. , Unterman T.G. , Cohen P.
Biochem. J.355:597-607(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-329;MUTAGENESIS OF SER-329
10.

"Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting."
Rena G. , Prescott A.R. , Guo S. , Cohen P. , Unterman T.G.
Biochem. J.354:605-612(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YWHAG AND YWHAZ;PHOSPHORYLATION AT THR-24; SER-256 AND SER-319;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-24; SER-256 AND SER-319
11.

"Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion."
Rena G. , Woods Y.L. , Prescott A.R. , Peggie M. , Unterman T.G. , Williams M.R. , Cohen P.
EMBO J.21:2263-2271(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-24; SER-256; SER-319; SER-322; SER-325 AND SER-329
12.

"Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding."
Zhang X. , Gan L. , Pan H. , Guo S. , He X. , Olson S.T. , Mesecar A. , Adam S. , Unterman T.G.
J. Biol. Chem.277:45276-45284(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-24; SER-256 AND SER-319
13.

"Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."
Daitoku H. , Hatta M. , Matsuzaki H. , Aratani S. , Ohshima T. , Miyagishi M. , Nakajima T. , Fukamizu A.
Proc. Natl. Acad. Sci. U.S.A.101:10042-10047(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CREBBP AND SIRT1;ACETYLATION;DEACETYLATION;FUNCTION
14.

"The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription."
Perrot V. , Rechler M.M.
Mol. Endocrinol.19:2283-2298(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EP300;ACETYLATION;SUBCELLULAR LOCATION;PHOSPHORYLATION;FUNCTION
15.

"Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation."
Huang H. , Regan K.M. , Wang F. , Wang D. , Smith D.I. , van Deursen J.M. , Tindall D.J.
Proc. Natl. Acad. Sci. U.S.A.102:1649-1654(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKP2;UBIQUITINATION;MUTAGENESIS OF SER-256
16.

"Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt."
Yamagata K. , Daitoku H. , Takahashi Y. , Namiki K. , Hisatake K. , Kako K. , Mukai H. , Kasuya Y. , Fukamizu A.
Mol. Cell32:221-231(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRMT1
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons."
Yuan Z. , Becker E.B.E. , Merlo P. , Yamada T. , DiBacco S. , Konishi Y. , Schaefer E.M. , Bonni A.
Science319:1665-1668(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-249 BY CDK1;INTERACTION WITH CDK1 AND 14-3-3 PROTEINS;MUTAGENESIS OF SER-249
19.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Regulation of neuronal cell death by MST1-FOXO1 signaling."
Yuan Z. , Lehtinen M.K. , Merlo P. , Villen J. , Gygi S. , Bonni A.
J. Biol. Chem.284:11285-11292(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-212;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF SER-212
21.

"Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity."
Zhao Y. , Yang J. , Liao W. , Liu X. , Zhang H. , Wang S. , Wang D. , Feng J. , Yu L. , Zhu W.G.
Nat. Cell Biol.12:665-675(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-262; LYS-265 AND LYS-274;DEACETYLATION BY SIRT2;FUNCTION IN AUTOPHAGY;INTERACTION WITH SIRT2 AND ATG7
22.

"KRIT1 regulates the homeostasis of intracellular reactive oxygen species."
Goitre L. , Balzac F. , Degani S. , Degan P. , Marchi S. , Pinton P. , Retta S.F.
PLoS ONE5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
23.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner."
Valis K. , Prochazka L. , Boura E. , Chladova J. , Obsil T. , Rohlena J. , Truksa J. , Dong L.F. , Ralph S.J. , Neuzil J.
Cancer Res.71:946-954(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-212
25.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification."
Brent M.M. , Anand R. , Marmorstein R.
Structure16:1407-1416(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 151-266;DNA-BINDING;PHOSPHORYLATION AT SER-212; SER-218; SER-234 AND SER-235;ACETYLATION;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-249

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